第42回生態適応セミナー (Bセミナー)

Professor Enrique Amaya (The Healing Foundation Centre, University of Manchester(UK))
 
  Learning the Secrets of Scarless Wound Healing and Tissue Regeneration  
     
  日時 6月18日(金曜日)17:30‐  
  場所 東北大学青葉山生物棟 一階 大会議室  
   
 

外敵あるいは外部環境変化から生物が身を守る方法は数多くありますが、動物に おける顕著な防御反応に、免疫、創傷治癒、再生、といった現象があります。 Amaya先生は今から15年ほど前にトランスジェニックカエル作成技術を世界に 先駆けて考案し、現在この技術を活かして炎症、創傷治癒、組織再生、を分子・ 細胞レベルで研究を行っている、世界中から注目を浴びている研究者です。イギ リスでは、ヒトの組織器官再生を目指す Healing Foundationという基金(慈善 団体)が向こう25年間にわたり毎年£10 millionを投じ、マンチェスター大学 に炎症、創傷治癒、組織再生の基礎と応用を研究する研究所を設立し研究を続け ています。その研究所のヘッドをされているAmaya先生に、イギリスにおける基 礎研究と応用研究の連携の現状についてもお聞きしたいと思っています。
参考文献: Science. 2010. 328:633-636, Blood. 2009. 114:40-48, EMBO Rep. 2007. 8:287-292.

(要旨) A major goal in regenerative medicine is to understand and ultimately facilitate our body’s ability to repair itself following injury. As a first step toward this goal, we are investigating the molecular and cellular mechanisms responsible for wound healing and tissue regeneration using frog embryos and tadpoles as our model of choice. Amphibian embryos and tadpoles have remarkable capacities to heal wounds quickly and efficiently, without leaving a scar, and to regenerate complex tissues following injury. For this reason embryos and tadpoles have much to teach us about how to heal perfect wounds and how to regenerate tissues. It has previously been suggested that inflammation is inhibitory to perfect wound healing and regeneration, and that embryos do not mount an inflammatory response, thus providing an explanation for why embryos heal wounds perfectly. We have recently shown that this is not the case, as embryos do mount an inflammatory response following injury. We are now describing the molecular mechanisms that lead to the specification and function of inflammatory cells during wound healing in embryos and tadpoles. We envision that this work will form the foundation for developing novel therapies, which will promote more efficient regenerative healing in human patients.